Rejuran

Rejuran is an injectable skin treatment made from polynucleotides (DNA fragments derived from salmon). Unlike dermal fillers, it does not add volume but instead supports the skin’s own repair and rejuvenation processes. Rejuran encourages collagen production, improves skin texture, reduces pigmentation, and softens superficial scarring. Because of its healing and anti-inflammatory effects, it is often described as a “skin healer.”

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How does Rejuran work?

Rejuran is delivered into the skin using micro-injections. Once in the skin, the polynucleotides work to:

• Stimulate collagen in the superficial layers – reducing pore size and smoothing fine lines.
• Enhance light reflection – improving the skin’s radiance and glow.
• Reduce melanin activity – helping to fade melasma and other pigmentation concerns.
• Support skin repair – calming inflammation and strengthening the skin barrier.
• Complement laser treatments – Rejuran can boost the collagen-stimulating effects of fractional and pigment lasers, and also helps to calm the inflammation that may follow procedures such as laser resurfacing.

The Secret to “Glass Skin” in Korea

The term “glass skin” refers to skin that appears clear, radiant, and almost translucent. Achieving this look often requires more than skincare products – it is the result of combining advanced laser technology with collagen-stimulating injectables.

• PicoSure® Laser: clears surface pigmentation such as freckles, sun spots, and uneven tone, while also smoothing skin texture with gentle collagen stimulation.
• Rejuran Injections: work at a deeper level to increase light reflectance, stimulate collagen, and calm inflammation, leaving the skin stronger and more luminous.

Together, these treatments target both the surface clarity and the underlying structure of the skin, making them one of the most effective combinations for achieving the glowing, even-toned appearance often described as “glass skin.”

What can Rejuran improve?

• Fine lines and early wrinkles
• Enlarged pores
• Dull or uneven skin tone
• Pigmented acne scars and superficial scarring
• Melasma and pigmentation

How is Rejuran different from Hyaluronic Acid (HA) skin boosters?

Both Rejuran and HA skin boosters improve skin quality, but they work in different ways:

• Rejuran: Repairs skin, stimulates collagen, reduces inflammation, and improves pigmentation.
• HA Skin Boosters: Hydrate and plump the skin by binding water, improving elasticity and suppleness.

HA boosters are best for hydration, while Rejuran focuses on healing, collagen stimulation, and light reflectance. They can be combined for a more complete skin rejuvenation program.

Safety of Rejuran

Rejuran has been used safely in Asia for more than 10 years and has a well-established track record. Side effects are generally mild and temporary, such as small bumps at the injection sites, redness, swelling, or bruising. These typically settle within 24–48 hours.

What to expect on the day of treatment

Because Rejuran involves multiple micro-injections across the treatment area, the procedure can be painful without adequate pain relief. Pain management is an important part of the process:

• Preparation: A topical anaesthetic cream is applied for 30–45 minutes before treatment.
• Pain relief options: To reduce discomfort, your doctor may:
  • Mix a small amount of local anaesthetic with the Rejuran solution
  • Offer Entonox (“happy gas”) for added comfort during the procedure
• Treatment time: Around 30–45 minutes.
• Downtime:
  • With superficial injections, small visible bumps may last for 24–48 hours. Gentle massage after 24 hours can help them settle.
  • With deeper injections, swelling usually resolves within 12 hours.
  • Mild redness or bruising may occur and usually settles within a few days.

How many sessions are needed?

A typical protocol involves three sessions spaced 2-6 weeks apart. After the initial course, 1–2 maintenance treatments per year are often recommended.

When will I see results?

Many patients notice improved hydration and glow within 3 weeks. Collagen remodelling and longer-lasting improvements in texture, tone, and pigmentation typically develop over 3–6 months.

Can Rejuran be combined with other treatments?

Yes. Rejuran can be performed on its own or in combination with other skin treatments such as:

• PicoSure® laser for pigmentation and skin texture
• Fractional resurfacing lasers for collagen renewal
• Other rejuvenation treatments for overall skin quality

Frequently Asked Questions (FAQ)

Is the treatment painful?

Rejuran is delivered through multiple fine injections, and most patients describe the procedure as stinging or uncomfortable without numbing. To make it more tolerable, numbing cream, local anaesthetic, and options like Entonox are used. Pain management is considered an essential part of treatment planning.

What is the downtime?

Small bumps at the injection sites are expected for 1–2 days. Redness, swelling, or mild bruising may occur but typically settles within a few days.

How many sessions are recommended?

Usually three treatments 4–8 weeks apart, followed by yearly maintenance.

When will I see results?

Glow and hydration may appear within weeks, with longer-lasting collagen remodelling over 3–6 months.

Is Rejuran safe?

It has been used safely for over a decade in Asia. Side effects are temporary and mild in most cases.

How does it differ from HA boosters?

HA boosters mainly rehydrate and plump the skin, while Rejuran repairs, remodels collagen, reduces inflammation, and improves pigmentation.

What’s the role of Rejuran and PicoSure® in achieving “glass skin”?

PicoSure® clears surface pigment and refines texture, while Rejuran increases light reflectance and stimulates collagen at a deeper level. Together, they provide both clarity and structure, creating the luminous, smooth appearance known as glass skin.

Key points to remember

• Rejuran is a skin healing and collagen-supporting injectable.
• Pain management is important, as injections can sting without numbing or comfort measures.
• Rejuran is especially effective when combined with laser treatments, as lasers clear surface pigment while Rejuran enhances light reflection and collagen stimulation.
• This combination is widely used in Korea to achieve the luminous “glass skin” effect.
• Best results are achieved with a course of treatments, and maintenance may be required.
• A consultation is required to confirm suitability.